Seeking Global Awareness for Millions of Sufferers 

About Dupuytren

(Source:  Dupuytren Research Group

Dupuytren's Disease has many related diseases:  Ledderhose Disease, Peyronie's Disease, Frozen Shoulder and Garrod's Pads.  Each of these related diseases or conditions is explained on separate pages of this website.

Welcome to Our Dupuytren's Disease Support Group

Dupuytren's Disease
Also known as Palmar Fibromatosis
We now know that early intervention brings the best results.

Impact of Dupuytren Disease 
(Source:  Dupuytren Research Group

Imagine the prospect of being unable to use your hands normally to wash, to reach into your pocket, use a keyboard or even shake hands. Imagine this worsening and being told there is nothing you can do to stop this that your only option is a procedure which probably won’t last and might make things worse.

Imagine passing this risk on to your children and to their children. Multiply this by millions, and you’ve still only imagined part of Dupuytren disease.This is an inherited disease spectrum affecting one or more areas including hands (Dupuytren contracture), feet (Ledderhose disease), penis (Peyronie disease), or shoulder (Frozen Shoulder). People with Dupuytren contracture also have greater
risk for other conditions including cardiovascular disease, cancer, and early death.
In the US alone an estimated10 million people are affected

Dupuytren disease is one of a group of diseases which result in fibrosis, or scar tissue where it isn’t needed. Part of the biology of Dupuytren disease overlaps that of other fibrotic conditions including cirrhosis of the liver, pulmonary fibrosis and circulatory problems from arteriosclerosis. Part of the biology overlaps that of some types of cancers.  If the root cause of Dupuytren disease can be understood, it may help physicians and researchers understand these other conditions and develop better treatments for them as well.

Dupuytren’s contracture is a benign condition which causes a tightening of the flesh beneath the skin of the palm and can result in permanently bent fingers. There is a sheet of tissue just under the skin of the palm which is stuck to the under surface of the skin of the palm. This layer, called fascia, reinforces the skin of the palm. The medical definition of Dupuytren’s is a specific condition characterized by proliferation of contractile, fibroblastic cells involving the palmar fascia of the hand. It is chronic and progressive. Involved areas show microscopic inflammation, similar to that seen in wound healing and some types of cancer, as though the body were healing a deep wound beneath the skin.